Having been born and reared in that southern Indiana town, Ezra Dee Alexander graduated from Bloomington High School in 1910. He matriculated at Indiana University in the fall of 1910 and graduated from Indiana University in 1917 with the A.B. degree. He received his M.D. degree from the Medical School of Indiana University in 1919. He practiced medicine in Indianapolis. In 1920, he married Mary Hunter, a teacher in the Indianapolis Public School system. Ezra Dee Alexander served several terms as a member of the Grand Board of Directors.